5-Methoxycarbonylmethyl-2-thiouridine

安庆5-Methoxycarbonylmethyl-2-thiouridine

Naturally-occurring RNA-modified nucleoside mcm5s2U, isolated from yeast tRNA, for vaccine and cancer research. It is a nucleoside in the anticodon at the wobble position of some Saccharomyces cerevisiae bacteria. It can be used in biological study for attomole quantification and global profile of RNA modifications in study of human neural stem cells.

5-Methoxycarbonylmethyl-2-thiouracil

安庆5-Methoxycarbonylmethyl-2-thiouracil

Used to glycosylation with carbohydrates for the synthesis of modified thio-pyrimidine nucleosides

2’-O-Methyl-N1-methyl adenosine

安庆2’-O-Methyl-N1-methyl adenosine

Naturally-occurring RNA modified nucleoside m1Am found in tRNA for vaccine and cancer research. It is a structural isomer of N6-methyl adenosine (m6A), which is the most abundant internally modified base in messenger RNA (mRNA) and non-coding RNA (ncRNA) in eukaryotic cells. It was also found from different organisms, including yeast, plants, and human cells. Its monophosphate is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. It has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications. It has been shown to play a role in regulating gene expression and RNA stability.

2’-O-Methyl inosine

安庆2’-O-Methyl inosine

Naturally-occurring RNA modified ribonucleoside Im for Vaccine and cancer research, an essential nucleoside found in the tRNA of all organisms. It is a component of rRNA of Crithidia fasciculata. It has intrinsic hypotensive activity and it is also an apoptosis- inducing nucleoside (AINs). It plays a pivotal role in unraveling the intricacies of inosine’s function within tRNA and other nucleic acid structures. 2’-O-Methylinosine has found extensive use across various applications. It has proven instrumental in studying the structural and functional aspects of tRNA, shedding light on the influence of inosine on tRNA’s properties. Investigations into other nucleic acids have also relied on the utilization of 2’-O-methyl inosine to decipher their structure and function. The versatility of this modified nucleoside extends to the examination of gene expression and the intricate regulation mechanisms. In terms of its mechanism of action, 2’-O-methylinosine is believed to act as a faithful mimic of inosine within tRNA. Consequently, it exhibits the capability to bind to the same nucleotides as inosine, enabling interactions with tRNA in a manner akin to that of its natural counterpart. Through these interactions, 2’-O-methyl inosine exerts an influence on the structure and function of tRNA. Additionally, it has been observed to act as an inhibitor of protein synthesis, effectively impeding the translation of mRNA into proteins. Used for phosphoramidite synthesis and modified RNA synthesis.

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