西安2’-O-Methylguanosine

Naturally-occurring RNA modified nucleoside Gm for vaccine and cancer research. It is a component of many nucleic acids and is usually found as a minor component in RNA. It is produced in tRNAs by the action of tRNA guanosine-2’-O-methyl transferase, using S-adenosyl-L-methionine as a substrate. This modification increases the stability of RNAs and antisense drugs. It has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme’s active site.

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西安Nucleoside Derivatives

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产品描述

Catalog No.	P1153
Name	2’-O-Methylguanosine
Synonyms
中文名称	2’-甲氧基鸟苷
Formula	C11H15N5O5
FW	297.27
CAS No.	2140-71-8
Purity	≥ 98%
Property	Appearance and Property: white or off-white solid m. p.: 227–231 ℃ Solubility: slightly soluble in DMSO and water Storage: sealed at 2–8 °C or at room temperature
Package	Packed as desired
Classification	Nucleoside Derivatives
Application & Biological Property	Naturally-occurring RNA modified nucleoside Gm for vaccine and cancer research. It is a component of many nucleic acids and is usually found as a minor component in RNA. It is produced in tRNAs by the action of tRNA guanosine-2’-O-methyl transferase, using S-adenosyl-L-methionine as a substrate. This modification increases the stability of RNAs and antisense drugs. It has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme’s active site.
References	1. Persson, B. C., Jäger, G.; Gustafsson, C. Nucleic Acids Res. 1997, 25, 4093-4097. 2. Yamagami, R.; Tomikawa, C.; Shigi, N.; et al. Genes Cells 2016, 21, 740-754.