6-Azauridine
6-Azauridine

驻马店6-Azauridine

White or off-white solid Storage: sealed container at 2–8 °C or at room temperature

类别：

驻马店Nucleoside Derivatives

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询价

产品描述

Catalog No.P1001
Name6-Azauridine
SynonymsAzauridine; 6-Azauracil riboside; 1-(beta-D-Ribofuranosyl)-6-azauracil
FormulaC8H11N3O6
FW245.19
CAS No.54-25-1
HPLC≥ 97%
PackagePacked as desired
ClassificationDrug substance; Nucleoside derivative
PropertyAppearance and Property: white solid powder; Hygroscopic
m. p.: 160-161 °C (lit.)
Density: 1.4866 g/cm3 (estimated)
Solubility: soluble in water, slightly soluble in DMSO, methanol, ethanol, pyridine
Storage: sealed at 2-8 °C or room temperature
Acidity (pKa): 6.70 (at 25 ℃)
Application & Biological PropertyAntimetabolic antineoplastic drug; 
Anti-bacterial, antitumor, and antiviral agent; Substrate of uridine kinase; Competitive inhibitor of orotidine 5’-phosphate decarboxylase
Toxicity: LD50 oral: > 316 mg/kg
References
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  2. McPartland, R. P.; Wang, M. C.; Bloch, A.; Weinfeld, H. Cancer Res. 1974, 34, 3107.
  3. Brockman, R. W.; Shaddix, S. C.; Williams, M.; Nelson, J. A.; Rose, L. M.; Schabel, F. M., Jr. Ann. N.Y. Acad. Sci. 1975, 255, 501.
  4. Robins, M. J.; Currie, B. L.; Robins, R. K.; Bloch, A. Proc. Am. Assoc. Cancer Res. 1969, 10, 73.
  5. Khare, G. P.; Sidwell, R. W.; Huffman, J. H.; Tolman, R. L.; Robins, R. K. Proc. Soc. Exp. Biol. Med. 1972, 140, 880.
  6. Shannon, W. M.; Brockman, R. W.; Westbrook, L.; Shaddix, S.; Schabel, F. M.; Jr. J. Natl. Cancer Inst. 1974, 52, 199.
  7. Shannon, W. M.; Arnett, G.; Schabel, F. M., Jr. Antimicrob. Agents Chemother. 1972, 2, 159.
  8. Handschumacher, R. E. J. Biol. Chem. 1960, 235, 764.

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