4-Deoxyuridine; Zebularine
4-Deoxyuridine; Zebularine

驻马店4-Deoxyuridine; Zebularine

Anticancer drug; cytidine deaminase inhibitor, epigenetic inhibitor; DNA methylation inhibitor, DNA methyl transferase inhibitor;

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产品描述

Catalog No. P1002
Name 4-Deoxyuridine; Zebularine
Synonyms 1-beta-D-Ribofuranosyl-2-(1H)-pyrimidinone; 1-beta-D-Ribofuranosyl -l ,2-dihydropyrimidin-2-one; Pyrimidin-2-one-D-ribofuranoside; NSC309132
Formula C9H12N2O5
FW 228.202
CAS No. 3690-10-6
HPLC ≥ 97%
Package Packed as desired
Classification Drug substance; Nucleoside derivative
Property Appearance and Property: white or off-white
m. p.: 170-171 °C (lit.)
Density: 1.7300 g/cm3 (estimated)
Solubility: soluble in DMSO (22.8 mg/mL, 100 mM); water (22.8 mg/mL, 100 mM)
Storage: sealed at 2-8 °C or room temperature
Acidity (pKa): 13.48 (Predicted)
[a]D13.7 +91.89° (c = 1.48, H2O)
Application & Biological Property Anticancer drug; cytidine deaminase inhibitor, epigenetic inhibitor; DNA methylation inhibitor, DNA methyl transferase inhibitor; 
References
  • Zhou L, et al. J. Mol. Biol., 2002, 321(4), 591-599.
  • Lemaire M, et al. Cancer Chemother. Pharmacol., 2009, 63(3), 411-416.
  • Cheng JC, et al. J. Natl. Cancer Inst., 2003, 95(5), 399-409.
  • Cheng JC, et al. Cancer Cell, 2004, 6(2), 151-158.

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