驻马店5-Chloro-2’-deoxyuridine

Appearance and Property: white or off-white solid; m. p.: 176–179 °C (lit.) Solubility: soluble in DMSO, slightly soluble in methanol and water Storage: sealed at 2–8 °C or room temperature Acute Toxicity: LD50 (IP, rats): > 2000 mg/kg Anticancer agent; Radio-sensitizing agent for cancer treatment; 可用于研究次氯酸对DNA和DNA前体的破坏作用。When 5-Chloro-2’-deoxy uridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-chloro-2’-deoxyuridine in the media does not alter cell division kinetics. It is metabolized and incorporated into DNA using antibodies that binds electively to DNA containing halogenated bases. It is more similar to BrdU in acting as a T analog. The toxicity of 5-chloro-2’-deoxy uridine could in part be attributed to inhibition of thymidylate synthase.

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驻马店Nucleoside Derivatives

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产品描述

Catalog No.	P1118
Name	5-Chloro-2’-deoxyuridine
Synonyms
中文名称	5-氯-2’-脱氧尿嘧啶核苷
Formula	C9H11ClN2O5
FW	262.65
CAS No.	50-90-8
Purity	≥ 98%
Property	Appearance and Property: white or off-white solid; m. p.: 176–179 °C (lit.) Solubility: soluble in DMSO, slightly soluble in methanol and water Storage: sealed at 2–8 °C or room temperature Acute Toxicity: LD₅₀ (IP, rats): > 2000 mg/kg
Package	Packed as desired
Classification	Nucleoside Derivatives 核苷衍生物
Application & Biological Property	Anticancer agent; Radio-sensitizing agent for cancer treatment; 可用于研究次氯酸对DNA和DNA前体的破坏作用。When 5-Chloro-2’-deoxy uridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-chloro-2’-deoxyuridine in the media does not alter cell division kinetics. It is metabolized and incorporated into DNA using antibodies that binds electively to DNA containing halogenated bases. It is more similar to BrdU in acting as a T analog. The toxicity of 5-chloro-2’-deoxy uridine could in part be attributed to inhibition of thymidylate synthase.
References