驻马店2’-O-Methyl-N1-methyl adenosine

Naturally-occurring RNA modified nucleoside m1Am found in tRNA for vaccine and cancer research. It is a structural isomer of N6-methyl adenosine (m6A), which is the most abundant internally modified base in messenger RNA (mRNA) and non-coding RNA (ncRNA) in eukaryotic cells. It was also found from different organisms, including yeast, plants, and human cells. Its monophosphate is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. It has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications. It has been shown to play a role in regulating gene expression and RNA stability.

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驻马店Nucleoside Derivatives

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产品描述

Catalog No.	P1126
Name	2’-O-Methyl-N¹-methyl adenosine
Synonyms
中文名称	N¹-甲基-2’-O-甲基腺苷
Formula	C12H17N5O4
FW	295.29
CAS No.	91101-00-7
Purity	≥ 98%
Property	Appearance and Property: white or off-white solid, hygroscopic Solubility: slightly soluble in DMSO, methanol and acidic water Storage: sealed at 2–8 °C or room temperature
Package	Packed as desired
Classification	Nucleoside Derivatives
Application & Biological Property	Naturally-occurring RNA modified nucleoside m¹Am found in tRNA for vaccine and cancer research. It is a structural isomer of N⁶-methyl adenosine (m⁶A), which is the most abundant internally modified base in messenger RNA (mRNA) and non-coding RNA (ncRNA) in eukaryotic cells. It was also found from different organisms, including yeast, plants, and human cells. Its monophosphate is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. It has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications. It has been shown to play a role in regulating gene expression and RNA stability.
References