2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside

驻马店2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside

2-Amino-6-chloro-9-(2'-deoxy-beta-D-ribofuranosyl)purine is a novel nucleoside with anticancer and antiviral properties. It is an activator of the ribonucleoside diphosphate (RND) cycle, which is the metabolic pathway for deoxyribonucleotide synthesis. It has been shown to inhibit viral replication and tumor cell proliferation. It is an indispensable compound in the realm of biomedical research with widespread utilization in the profound exploration of nucleoside analogs’ impact on DNA synthesis and replication.

5-Chloro-2’-deoxyuridine

驻马店5-Chloro-2’-deoxyuridine

Appearance and Property: white or off-white solid; m. p.: 176–179 °C (lit.) Solubility: soluble in DMSO, slightly soluble in methanol and water Storage: sealed at 2–8 °C or room temperature Acute Toxicity: LD50 (IP, rats): > 2000 mg/kg Anticancer agent; Radio-sensitizing agent for cancer treatment; 可用于研究次氯酸对DNA和DNA前体的破坏作用。When 5-Chloro-2’-deoxy uridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-chloro-2’-deoxyuridine in the media does not alter cell division kinetics. It is metabolized and incorporated into DNA using antibodies that binds electively to DNA containing halogenated bases. It is more similar to BrdU in acting as a T analog. The toxicity of 5-chloro-2’-deoxy uridine could in part be attributed to inhibition of thymidylate synthase.

2’-Deoxy-2’-fluoro-b-D-arabinocytidine;

驻马店2’-Deoxy-2’-fluoro-b-D-arabinocytidine;

Application & Biological Property Anticancer agent; Metabolite of Fiacitabine (FIAC); Related substance of Azvudine抗肿瘤药、非西他滨代谢物、阿兹夫定有关物质

6-Deaminoadenosine, Nebularine

驻马店6-Deaminoadenosine, Nebularine

Natural nucleoside isolated from mushroom Agaricus (Clitocybe) nebularis Batsch (真菌水粉杯伞菌)； Anti-bacterial, anticancer, antineoplastic, and antifungal Agents; Strong competitive inhibitor of adenosine deaminase抗菌抗肿瘤抗真菌药物； Toxicity: LD50 (rats, guinea pigs): 220 mg/kg, s.c.

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