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5-Trifluoromethyl-2’-deoxyuridine; Trifluridine

Catalog No:

Classification：

Nucleoside Derivatives

Application & Biological Property：

Antiviral anticancer drug, DNA/RNA synthesis inhibitor, DNA polymerase inhibitor, viral replication inhibitor, bio-reagent; Toxicity: LD50 (IP), 1931 mg/kg
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Product Details

Catalog No. P1008

 
Name 5-Trifluoromethyl-2’-deoxyuridine; Trifluridine
Synonyms Viroptic, Trifluorothymidine, F3Thd
Formula C10H11F3N2O5
FW 296.20
CAS No. 70-00-8
HPLC ≥ 97%
Package Packed as desired
Classification Drug substance; Nucleoside derivative
Property Appearance and Property: white to off-white solid
m. p.: 190-193 °C (lit.)
Density: 1.436 g/cm3 (estimated)
Solubility: soluble in DMSO (25 mg/mL) and water (14 mg/mL)
Storage: sealed vial at 2-8 °C or room temperature
Acidity (pKa): 7.85 (Predicted)
Application & Biological Property Antiviral anticancer drug, DNA/RNA synthesis inhibitor, DNA polymerase inhibitor, viral replication inhibitor, bio-reagent; 
Toxicity: LD50 (IP), 1931 mg/kg
References
              1. Gottschling C., Heidelberger, C., J. Mol. Biol. 1963, 7, 541.
              2. Heidelberger, C., Cancer Res. 1970, 30, 1549.
              3. Umeda, M., Heidelberger, C., Cancer Res. 1968, 28, 2529.
              4. Heidelberger C., Anderson, S. W., Cancer Res. 1964, 24, 1979.
              5. Fujiwara, Y., Oki, T., Heidelberger, C., Mol. Pharmacol. 1970, 6, 273.
              6. Santi, D. V., Sakai, T. T., Biochemistry 1971, 10, 3598.

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