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6-Deaminoadenosine, Nebularine

Catalog No:

Classification：

Drug Substances

Application & Biological Property：

Natural nucleoside isolated from mushroom Agaricus (Clitocybe) nebularis Batsch ； Anti-bacterial, anticancer, antineoplastic, and antifungal Agents; Strong competitive inhibitor of adenosine deaminase； Toxicity: LD50 (rats, guinea pigs): 220 mg/kg, s.c.
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Product Details

Catalog No. P003
Name 6-Deaminoadenosine, Nebularine
Synonyms 9-(beta-D-Ribofuranosyl)-9H-purine; Purine riboside
Formula C10H12N4O4
FW 252.227
CAS No. 550-33-4
HPLC ≥ 97%
Package Packed as desired
Classification Drug substance; Nucleoside derivative
Property Appearance and Property: white solid; hygroscopic
m. p.: 181-182 °C (lit.)
Density: 1.3402 g/cm3 (estimated)
Solubility: soluble in DMSO, water and methanol; slightly soluble in ethanol; insoluble in chloroform, diethyl ether and acetone;
Storage: sealed at 2-8 °C or room temperature
Acidity (pKa): 13.13 (Predicted)
[a]D25 -48.6° (c = 1.5, H2O)
Application & Biological Property Natural nucleoside isolated from mushroom Agaricus (Clitocybe) nebularis Batsch 
Anti-bacterial, anticancer, antineoplastic, and antifungal Agents; Strong competitive inhibitor of adenosine deaminase
Toxicity: LD50 (rats, guinea pigs): 220 mg/kg, s.c.
References
  • T. Takeda, Y. Ohashi, Y. Sasada, Acta Cryst. 1974, B30, 825-827.
  • G. B. Brown, V. S. Weliky, J. Biol. Chem. 1953, 204, 1019-1024.
  • J. G. Cory, R. J. Suhadolnik, Biochemistry 1965, 4, 1729.
  • R. Wolfenden, J. Kaufman, J. B. Macon, Biochemistry 1969, 8, 2412.

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6-Deaminoadenosine, Nebularine

6-Deaminoadenosine, Nebularine

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