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2’-O-Methyl inosine

Catalog No:

Classification：

Nucleoside Derivatives

Intermediates and Building Blocks

Application & Biological Property：

Naturally-occurring RNA modified ribonucleoside Im for Vaccine and cancer research, an essential nucleoside found in the tRNA of all organisms. It is a component of rRNA of Crithidia fasciculata. It has intrinsic hypotensive activity and it is also an apoptosis- inducing nucleoside (AINs). It plays a pivotal role in unraveling the intricacies of inosine’s function within tRNA and other nucleic acid structures. 2’-O-Methylinosine has found extensive use across various applications. It has proven instrumental in studying the structural and functional aspects of tRNA, shedding light on the influence of inosine on tRNA’s properties. Investigations into other nucleic acids have also relied on the utilization of 2’-O-methyl inosine to decipher their structure and function. The versatility of this modified nucleoside extends to the examination of gene expression and the intricate regulation mechanisms. In terms of its mechanism of action, 2’-O-methylinosine is believed to act as a faithful mimic of inosine within tRNA. Consequently, it exhibits the capability to bind to the same nucleotides as inosine, enabling interactions with tRNA in a manner akin to that of its natural counterpart. Through these interactions, 2’-O-methyl inosine exerts an influence on the structure and function of tRNA. Additionally, it has been observed to act as an inhibitor of protein synthesis, effectively impeding the translation of mRNA into proteins. Used for phosphoramidite synthesis and modified RNA synthesis.

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Product Details

Catalog No.	P1125
Name	2’-O-Methyl inosine
Synonyms
中文名称	2’-甲氧基肌苷
Formula	C11H14N4O5
FW	282.25
CAS No.	3881-21-8
Purity	≥ 98%
Property	Appearance and Property: white or off-white solid m. p.: 153–156 °C Solubility: soluble in DMSO, slightly soluble in water Storage: sealed at 2–8 °C or room temperature
Package	Packed as desired
Classification	Nucleoside Derivatives; Intermediates and Building Blocks
Application & Biological Property	Naturally-occurring RNA modified ribonucleoside Im for Vaccine and cancer research, an essential nucleoside found in the tRNA of all organisms. It is a component of rRNA of Crithidia fasciculata. It has intrinsic hypotensive activity and it is also an apoptosis- inducing nucleoside (AINs). It plays a pivotal role in unraveling the intricacies of inosine’s function within tRNA and other nucleic acid structures. 2’-O-Methylinosine has found extensive use across various applications. It has proven instrumental in studying the structural and functional aspects of tRNA, shedding light on the influence of inosine on tRNA’s properties. Investigations into other nucleic acids have also relied on the utilization of 2’-O-methyl inosine to decipher their structure and function. The versatility of this modified nucleoside extends to the examination of gene expression and the intricate regulation mechanisms. In terms of its mechanism of action, 2’-O-methylinosine is believed to act as a faithful mimic of inosine within tRNA. Consequently, it exhibits the capability to bind to the same nucleotides as inosine, enabling interactions with tRNA in a manner akin to that of its natural counterpart. Through these interactions, 2’-O-methyl inosine exerts an influence on the structure and function of tRNA. Additionally, it has been observed to act as an inhibitor of protein synthesis, effectively impeding the translation of mRNA into proteins. Used for phosphoramidite synthesis and modified RNA synthesis.
References	1. Hyde, R. M.; Broom, A. D.; Buchkeit, R. W. Jr. J. Med. Chem. 2003, 46, 1878–1885. 2. Dutta, N.; Deb, I.; Sarzynska, J.; Lahiri, A. Prog. Biophys. Mol. Biol. 2022, 169–170, 21–52. 3. Rottman, F.; Friderici, K.; Comstock, P.; Khan, M. D. Biochemistry 1974, 13, 2762–2771. 4. Yamada, T.; Kageyama, K.; Joh, Y.; Konishi, J.; Lenaga, K. Cell Mol. Life Sci. 1998, 54, 125–128. 5. Mori, T.; Gua, M.-W.; Li, X.; Xu, J.-P.; Mori, E. Biochem. Biophys. Res. Commun. 1998, 251, 416–422.