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2’-O-Methylguanosine

Catalog No:

Classification：

Nucleoside Derivatives

Application & Biological Property：

Naturally-occurring RNA modified nucleoside Gm for vaccine and cancer research. It is a component of many nucleic acids and is usually found as a minor component in RNA. It is produced in tRNAs by the action of tRNA guanosine-2’-O-methyl transferase, using S-adenosyl-L-methionine as a substrate. This modification increases the stability of RNAs and antisense drugs. It has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme’s active site.
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Product Details

Catalog No.

P1153

Name

2’-O-Methylguanosine

Synonyms

 

中文名称

2’-甲氧基鸟苷

Formula

C11H15N5O5

FW

297.27

CAS No.

2140-71-8

Purity

≥ 98%

Property

Appearance and Property: white or off-white solid

m. p.: 227–231 ℃

Solubility: slightly soluble in DMSO and water

Storage: sealed at 2–8 °C or at room temperature

Package

Packed as desired

Classification

Nucleoside Derivatives

Application & Biological Property

Naturally-occurring RNA modified nucleoside Gm for vaccine and cancer research. It is a component of many nucleic acids and is usually found as a minor component in RNA. It is produced in tRNAs by the action of tRNA guanosine-2’-O-methyl transferase, using S-adenosyl-L-methionine as a substrate. This modification increases the stability of RNAs and antisense drugs. It has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme’s active site.

References

1. Persson, B. C., Jäger, G.; Gustafsson, C. Nucleic Acids Res. 1997, 25, 4093-4097.

2. Yamagami, R.; Tomikawa, C.; Shigi, N.; et al. Genes Cells 2016, 21, 740-754.

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