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2’-O-Methyl-2-thiouridine

Catalog No:

Classification：

Nucleoside Derivatives

Intermediates and Building Blocks

Application & Biological Property：

Naturally-occurring RNA modified nucleoside s2Um for vaccine and cancer research. It exhibits antiviral activity against various viral infections, making it a potential therapeutic option for treating RNA virus-associated diseases. It has been shown to stabilize duplex DNA against thermal denaturation by forming triplexes with complementary sequences. It also stabilizes dsDNA against hydrolysis by the enzyme ribonuclease H (RNase H) and has been used in the design of antisense therapeutics. Thermophilic bacteria use this molecule to synthesize their own thymine nucleotides, which are structurally similar to 2’-O-methyl-2-thiouridine. Its unique properties and versatility make it an essential tool for studying RNA biology and developing antiviral therapies.
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Product Details

Catalog No.

P1158

Name

2’-O-Methyl-2-thiouridine

Synonyms

 

中文名称

2’-O-甲基-2-硫代尿苷

Formula

C10H14N2O5S

FW

274.29

CAS No.

113886-72-9

Purity

≥ 98%

Property

Appearance and Property: white or off-white solid

Storage: sealed at 2–8 °C or at room temperature

Package

Packed as desired

Classification

Nucleoside Derivatives; Intermediates and Building Blocks 

Application & Biological Property

Naturally-occurring RNA modified nucleoside s2Um for vaccine and cancer research. It exhibits antiviral activity against various viral infections, making it a potential therapeutic option for treating RNA virus-associated diseases. It has been shown to stabilize duplex DNA against thermal denaturation by forming triplexes with complementary sequences. It also stabilizes dsDNA against hydrolysis by the enzyme ribonuclease H (RNase H) and has been used in the design of antisense therapeutics. Thermophilic bacteria use this molecule to synthesize their own thymine nucleotides, which are structurally similar to 2’-O-methyl-2-thiouridine. Its unique properties and versatility make it an essential tool for studying RNA biology and developing antiviral therapies.

References

1, Prakash, T. P.; Naik, N.; Sioufi, N.; Bhat, B.; Swayze, E. E. Nucleosides, Nucleotides, Nucleic Acids 2009, 28, 902-910.

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