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Iso-cytidine

Catalog No:

P1169

Classification：

Nucleoside Derivatives

Application & Biological Property：

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Product Details

Structure

Catalog No.

P1169

Name

Iso-cytidine

Synonyms

 

中文名称

异胞苷

Formula

C9H13N3O5

FW

243.22

CAS No.

489-59-8

Purity

≥ 97%

Property

white or off-white solid

m. p. 125-128 °C

Storage: sealed container at 2–8 °C or at room temperature

Package

Packed as desired

Classification

Nucleoside Derivatives

Application & Biological Property

Used for further modified nucleosides or phosphoramidites; mRNA building blocks; It has been shown to stimulate growth in cell cultures. It also binds to messenger RNA and inhibits protein synthesis by interfering with the binding of aminoacyl-transfer ribonucleic acid (tRNA) to mRNA. This leads to a decrease in the amount of protein produced by the cell. Isocytidine also prevents cellular proliferation through its inhibition of fatty acid synthesis. This modification has implications for the stability and structure of RNA duplexes, as demonstrated by the thermodynamic properties measured through UV optical melting. The presence of isocytidine in RNA duplexes tends to stabilize them, and this effect is sequence-dependent. Research has shown that isocytidine is metabolized into isocytosine and uracil in Escherichia coli. Isocytidine has also been studied for its role in the stability and structure of RNA duplexes. It was found that replacements of guanosine (G) and cytidine (C) with isoguanosine (iG) and isocytidine (iC) generally stabilize duplexes, and this stabilization is sequence-dependent. These findings have implications for our understanding of the thermodynamic stabilities of nucleic acid duplexes and could inform the design of RNA-based therapeutics

References
  1. Dockocil, J.; Holy, A.; Filip, J. Nucleic Acid Res. 1974, 1, 1209-1220.
  2. Horn, T.; Chang, C.-A.; Collins, M. L. Tetrahedron Lett. 1995, 36, 2033-2036.
  3. Chen, X. Y.; Kierzek, R.; Turner, D. H. J. Am. Chem. Soc. 2001, 123, 1267-1274.

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