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3’,4’-Didehydro-3’-deoxycytidine

Catalog No:

P1303

Classification：

Nucleoside Derivatives

Biologically Important Derivatives

Application & Biological Property：

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Product Details

Catalog No.

P1303

Name

3’,4’-Didehydro-3’-deoxycytidine

Synonyms

3’-Deoxy-3’,4’-didehydro-cytidine; DDHC

中文名称

 

Formula

C9H11N3O4

FW

225.20

CAS No.

386264-46-6

Purity

≥ 97%

Property

white or off-white solid

Solubility: slightly soluble in DMSO and water

Storage: sealed container at room temperature

Package

Packed as desired

Classification

Nucleoside Derivatives; Biologically Important Derivatives

Application & Biological Property

This cytidine analogue has the ability to prevent the replication of several viruses, including the Zika virus. It is also naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin. It is a metabolite of 3’-deoxy-3’,4’-didehydro-CTP. It has a role as an antiviral agent, a human blood serum metabolite, a protein synthesis inhibitor and an RdRp polymerase inhibitor.  

References

1, Mehta, R.; Chekmeneva, E.; Jackson, H.; Sands, C. et. al. Med. 2022, 3, 204-215;

2, Lee, J. H.; Wood, J. M.; Almo, S. C.; Evans, G. B.; Harris, L. D. Grove, T. L. ACS Bio & Med. Chem. 2023, 3, 322-326.

3, Ebrahimi, K. H.; Howie, D.; Rowbotham, J. S.; McCullagh, J.; Armstrong, F. A.; James, W. S. FEBS Lett. 2020, 594, 1624-1630.

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